194
Phenotypes and endotypes of asthma
PRACTALL trigger‐based phenotypes
Severity should be assessed for each phenotype
Overlap between phenotypes is frequently present
*Children may also be atopic
# Different aetiologies, including irritant exposure and as‐yet not evident allergies may be included here
Bacharier LB, et al. Allergy 2008;63:5−34.
Is the child completely well
between symptomatic periods?
YES
NO
Does the child
have clinically
relevant allergic
sensitization?
Are colds the
most common
precipitating
factor?
Is exercise the
most common or
only precipitating
factor?
NO
NO
YES
YES
Virus‐induced
asthma*
Exercise‐induced
asthma*
YES
NO
Allergen‐induced
asthma
Unresolved
asthma*
#
Uncontrolled paediatric asthma
adversely affects parents and carers
•
Caregivers of children with uncontrolled asthma have been shown to have significantly greater
work and activity impairment, and lower quality of life for emotional, time‐related and family
activities
1
WPAI = Work Productivity and Activity Impairment.
1. Dean BB, et al. Health Qual Life Outcomes 2010;8:96.
Internet‐based survey of adult caregivers of children aged 6–12 years with
moderate‐to‐severe asthma
1
0
5
10
15
20
25
Work time absent
Impairment while
working
Overall work
productivity loss
Activity impairment
WPAI score (%)
Uncontrolled
Controlled
Simposium
