189
Marked reduction in seasonal asthma
exacerbations seen with omalizumab
•
A post‐hoc analysis revealed that omalizumab reduced seasonal spikes in asthma
exacerbations compared with placebo
Busse WW,
et al. N Engl J Med
2011;364:1005–15.
Width of the bands represents the 95% confidence interval
10
5
0
Exacerbations (%)
Placebo
Omalizumab
ICATA
Symptoms and exacerbations* were
reduced with omalizumab
*Defined as need for systemic corticosteroids, hospitalization or
both.
Busse WW,
et al. N Engl J Med
2011;364:1005–15.
Week
0
15
10
5
0
-4
12
24
36
36
60
Exacerbations* (%)
Run-in Wash-in
Omalizumab effect: 18.5% reduction in exacerbations (p<0.001)
Omalizumab (n=208)
Placebo (n=211)
Omalizumab effect: symptom reduction of 0.48 days/2 wk (p<0.001)
6
5
4
3
2
1
0
0 -4
12
24
36
36
60
Days with symptoms
(no./2 wk)
Run-in Wash-in
Week
ICATA
Simposium
